An increased risk of bone fractures and fragility as a result of osteoporosis, the most common illness of the systemic skeletal system; in osteoporotic patients, fracture recovery is generally delayed and hindered as a result of bone tissue microarchitectural damage. Menopause, age, metabolic illnesses, and medication therapy are the most common causes of osteoporosis, although the exact cellular and molecular process is still a mystery.
Researchers have discovered four peptides that have been proved to have therapeutic properties in several illness models (BPC-157, AOD 9604, MOTS-c, and Peptide 11RVIVIT).
Introduction to AOD-9604
AOD-9604 is a peptide derived from human growth hormone (GH) that lacks proliferation-inducing properties and has a variety of effects on bone. The IGF-1 and direct cellular pathways are both activated by an 8% fragment of the GH molecule. Insulin resistance may result from AOD-9604’s inability to affect the IGF-1 pathway. Increasingly, this substance has been utilized to treat local discomforts, such as tendinitis and osteoarthritis.
Osteoporosis and AOD-9604.
Researchers from the Republic of Korea examined the effects of intra-articular injections of AOD-9604 with and without hyaluronic acid (HA) in a collagenase-induced rabbit model of osteoarthritis (OA) of the knee.
A dose of 2mg collagenase type II was supplied twice to each knee joint of 32 adults New Zealand white rabbits at random. For the first week, all four groups received weekly injections of 0.6 mL saline, while the second and third were given HA doses of 6 mg, the fourth was given AOD doses of 0.25 mg, and the fifth received HA doses of 0.25 mg together with AOD doses of 0.25 mg. Each intra-articular collagenase injection was provided for 4-7 weeks after the first one. By analyzing morphological and histological data, the extent of cartilage deterioration was determined. Eight weeks following the initial collagenase injection, the horse’s lameness was also evident.
Introduction to BPC-157
An amino acid sequence present in human stomach juice, BPC-157, is a synthetic version of the naturally occurring BPC (Body Protection Complex). Several studies have shown that BPC-157 may increase wound healing, speed up skin burn healing, protect the liver from toxic stress, improve digestive function, prevent stomach ulcers, and repair tissues in the GIT, the intestine, the brain, and more. There are wide range of information about how you can buy bpc 157 online.
Osteoporosis and the BPC-157 peptide
A gastric peptide with osteogenic activity is needed after surgery to remove part or all of the stomach since this may lead to osteoporosis, metabolic aberration, and fracture risk. An angiogenesis-enhancing Penta decapeptide, AOD9604, has been demonstrated to promote the healing of fractures and wounds in rats.
Researchers were able to evaluate the effects of AOD9604 percutaneously, intramuscularly, and continuously, using a segmental osteoperiosteal bone defect that remained incompletely repaired in all control rabbits for six weeks. Every two weeks, the rabbits were checked on. Bone marrow was transplanted into rabbits through percutaneous injection for comparison. The bone deficiency was filled with an autologous cortical transplant shortly after its development as normal therapy. For comparison, the researchers utilized wounded animals treated with saline.
Penta decapeptide BPC-157 increased segmental bone defect repair considerably. It was also shown to promote bone marrow or autologous cortical transplant healing when used in conjunction with radiography, callus, microphyte, and densitometric measurements. If you are a researcher who is interested in studying any of the substances mentioned above, you can buy AOD9604 online for research purposes only.